- 中文名称
Anti-人CD5 PerCP-Cy 5.5(流式抗体)
- 英文名字
- Anti-Hu CD5 PerCP-Cy 5.5
- 供应商
- EXBIO
- 产品货号
- T9-691-T025
- 产品报价
- ¥已停产
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
- 应用类型
- FC (QC tested)
- 免疫原
- Human acute lymphoblastic leukemia (ALL) T cells
- 来源宿主
- 小鼠
- 反应性
- Human
- 保存建议
- Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
- 其他
- EXBIO是捷克一家著名的生物试剂公司,专注于流式细胞术配套试剂的开发。自1990年成立以来,EXBIO公司研发和制造的抗体分销全球。目前,EXBIO可提供超过4000种质优、价廉的研究和临床应用抗体,涵盖了血液学,免疫学,癌症,干细胞和细胞生物学等领域,如:CD分子、细胞粘附分子、细胞骨架、凋亡、细胞信号传导、肿瘤标志物、人血型、HLA、生殖等研究用抗体,涉及荧光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多达13种,满足客户各类实验需求。
- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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