- 中文名称
Troponin I, Cardiac, Human (cTnI, TNNC1) BioAssay ELISA Kit
- 英文名字
- Troponin I, Cardiac, Human (cTnI, TNNC1) BioAssay ELISA Kit
- 供应商
- USBiological
- 产品货号
- T8665-15S
- 产品报价
- ￥1/96Tests
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- 产品描述
- Intended Use:Troponin I, Human, BioAssay ELISA Kit is intended for the quantitative determination of cardiac troponin I in human serum. Measurement of troponin I values are useful in the research of acute myocardial infarction (AMI). Troponin is the inhibitory or contractile regulating protein complex of striated muscle. It is located periodically along the thin filament of the muscle and consists of three distinct proteins; troponin I, troponin C, and troponin T.1-5 Likewise, the troponin I subunit exists in three separate isoforms; two in fast-twitch and slow-twitch skeletal muscle fibers, and one in cardiac muscle. The cardiac isoform (cTnI) is about 40% dissimilar, has a molecular weight of 22,500 daltons, and has 31 additional amino acid residues that are not present on the skeletal isoforms. Antibodies made against this cardiac isoform are immunologically different from antibodies made against the other two skeletal isoforms, and the unique isoform and tissue specificity of cardiac troponin I is the basis for its use as an aid in the diagnosis of acute myocardial infarction. The most recently described and preferred biomarker for myocardial damage is cardiac troponin (I or T). The cardiac troponins exhibit myocardial tissue specificity and high sensitivity. Likewise, cardiac TnI and CK-MB have similar release patterns (4-6 hours after the onset of pain), but the level of cTnI remains elevated for a much longer period of time (6-10 days), thus providing for a longer window of detection of cardiac injury. Normal levels of cTn I in the blood are very low. After the onset of an AMI, cTnI levels increase substantially and are measurable in serum within 4 to 6 hours, with peak concentrations reached in approximately 12 to 24 hours after infarction. The fact that cTnI remains elevated in serum for a much longer period of time, added to its enhanced diagnostic sensitivity and cardiac specificity, allows for the detection of AMI much earlier after the onset of ischemia (4 hours), as well as the diagnosis of peri-operative infarction in situations where a high serum level of skeletal muscle proteins are expected. Additionally, recent data have identified a measurable relationship between cardiac troponin levels and long-term outcome after an episode of chest discomfort. The studies suggest that the use of the cTnI demonstrates high predictive value in delineating the high risk group of unstable angina patients, and that these tests may be particularly useful in evaluating patient condition prior to discharge from the ED. The United States Biological Troponin I, Human, BioAssay ELISA Kit provides a rapid, sensitive, and reliable assay for the quantitative measurement of cardiac-specific troponin I. The antibodies developed for the test will determine a minimal concentration of 1ng/ml, and there is no cross-reactivity with human cardiac troponin T or skeletal troponin T or I. Kit Components:T8665-15S1: Microtiter Plate: 1x96 wellsT8665-15S2: TnI Standard, 75ng/ml: 1x1vial T8665-15S3: TnI Standard, 30ng/ml: 1x1vial T8665-15S4: TnI Standard, 7.5ng/ml: 1x1vial T8665-15S5: TnI Standard, 2.0ng/ml: 1x1vialT8665-15S6: TnI Standard, 0ng/ml: 1x1vialT8665-15S7: Tnl (HRP) mouse x human: 1x13ml T8665-15S8: Tetramethylbenzidine (TMB): 1x11mlT8665-15S9: Stop Solution: 1x11ml (1N HCl) Storage and Stability: Store all components at 4°C. Reconstitute Standards (T8665-15S2-T8665-15S6) with 1ml ddH2O (20min, RT). Aliquot and store at -20°C. Kit contents are Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- 产品特点
- 针对Troponin I, Cardiac, Human (cTnI, TNNC1) BioAssay ELISA Kit该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Troponin I, Cardiac, Human (cTnI, TNNC1) BioAssay ELISA Kit产品后将其置于4°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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