Echinoderm microtubule-associated (EML) proteins function to modify the assembly dynamics of microtubules. EML4 (Echinoderm microtubule-associated protein-like 4), also known as EMAPL4, ELP120, C2orf2 or ROPP120, is a 981 amino acid cytoplasmic protein that contains nine WD repeats. Expressed at high levels during mitosis, EML4 is thought to modify the assembly dynamics of microtubules, specifically altering microtubules to become longer and more flexible. Due to a chromosomal inversion with chromosome 2p, EML4 may exist as a fusion protein with ALK (anaplastic lymphoma receptor tyrosine kinase), producing an EML4-ALK fusion complex that plays a role in the pathogenesis of lung cancer.
应用类型
WB | AM
免疫原
人 EML4 (AA223-229)蛋白Tyr226残基附近磷酸化肽
来源宿主
兔
反应性
人
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍10021多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Str
