TAK1 encoded by the gene MAP3K7, is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-B signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFKB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. TAK1 is important for TGF-B1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines.
应用类型
WB
免疫原
人TAK1 (400-500 aa) 合成肽, 钥孔血蓝蛋白 (KLH)螯合.
来源宿主
兔
反应性
大鼠 | 小鼠
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚,是一家生物科技公司,专门从事试剂与试剂盒研究,服务范围遍及6804多个国家。 StressMarq公司的核心技术领域为细胞应激(尤其是热休克蛋白(HSP)领域,领先全球),离子通道,载体研究,同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到:细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外,Str