- 中文名称
SCF, Recombinant, Human, CF (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)
- 英文名字
- SCF, Recombinant, Human, CF (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)
- 供应商
- USBiological
- 产品货号
- S7973-01B
- 产品报价
- ￥1/10ug
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- 产品描述
- Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40kD type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189aa extracellular domain (ECD), a 23aa transmembrane segment, and a 36aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25kD soluble molecule which is comparable to the only formproduced by Steel-dickie mutant mice. An alternatively spliced isoform of human SCF exists that lacks 28aa that encompass the primary proteolytic recognition site. Within the ECD of the long isoform (corresponding to this recombinant protein), human SCF shares 79%-87% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.Source:Recombinant protein corresponding to aa26-189 from human SCF expressed in HEK293.Molecular Weight:~18.5kDEndotoxin: ~1EU/1ug (LAL)Biological Activity:Measured in a cell proliferation assay using TF1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is typically 15ng/ml.Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- 产品特点
- 针对SCF, Recombinant, Human, CF (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到SCF, Recombinant, Human, CF (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)产品后将其置于-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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