该Phospho-HDAC6 (Ser22) Polyclonal Antibody. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
应用类型
WB,IHC-p,IF,ELISA
免疫原
Synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22
