该Phospho-IkB alpha (Ser32/S36) Polyclonal Antibody. Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
应用类型
WB,IHC-p,IF,ELISA
免疫原
Synthesized peptide derived from human IκB-α around the phosphorylation site of Ser32/36
