该Phospho-CHEK2 (Thr68) Polyclonal Antibody. Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
应用类型
WB,IHC-p,IF,ELISA
免疫原
Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68
