- 中文名称
Raf Family, Antibody Sampler Kit, BioAssay
- 英文名字
- Raf Family, Antibody Sampler Kit, BioAssay
- 供应商
- USBiological
- 产品货号
- R0495-12
- 产品报价
- ￥1/1Kit
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway (1). Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491, Ser494, Ser497 and Ser499 (2). p21-activated protein kinase (PAK) has been shown to phosphorylate c-Raf at Ser338 and the Src family phosphorylates Tyr341 to induce c-Raf activity (3,4). Ser338 of c-Raf corresponds to similar sites in A-Raf (Ser299) and B-Raf (Ser445), although this site is constitutively phosphorylated in B-Raf (5). Inhibitory 14-3-3 binding sites on c-Raf (Ser259 and Ser621) can be phosphorylated by Akt and AMPK, respectively (6,7). While A-Raf, B-Raf and c-Raf are similar in sequence and function, differential regulation has been observed (8). Of particular interest, B-Raf contains three consensus Akt phosphorylation sites (Ser364, Ser428 and Thr439) and lacks a site equivalent to Tyr341 of c-Raf (8,9). The B-Raf mutation V600E results in elevated kinase activity and is commonly found in malignant melanoma (10). Six residues of c-Raf (Ser29, Ser43, Ser289, Ser296, Ser301 and Ser642) become hyperphosphorylated in a manner consistent with c-Raf inactivation. The hyperphosphorylation of these six sites is dependent on downstream MEK signaling and renders c-Raf unresponsive to subsequent activation events (11).Kit Includes:QuantityApplicationsReactivityMW (kD)(1) Rabbit x Phospho-A-Raf (Ser299) Antibody20ulWBHuman Mouse (Rat)68kDRabbit(2) Rabbit x A-Raf Antibody20ulWB IPHuman Mouse Rat68kD(3) Rabbit x Phospho-c-Raf (Ser338) (mAb)20ulWBHuman Mouse Rat Monkey74kD(4) Rabbit x Phospho-c-Raf (Ser289/296/301)20ulWBHuman Mouse74kD(5) Rabbit x Phospho-c-Raf (Ser259)20ulWB IPHuman Mouse Rat Xenopus (Chicken)74kD(6) Rabbit x c-Raf Antibody20ulWB IPHuman Mouse Rat65 to 75kD(7) Rabbit x Phospho-B-Raf (Ser445)20ulWBHuman Mouse Rat Monkey (Chicken)86kD(8) Mouse x B-Raf (mAb)20ulWB IP FCHuman Mouse Rat Monkey86kD
- 产品特点
- 针对Raf Family, Antibody Sampler Kit, BioAssay该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Raf Family, Antibody Sampler Kit, BioAssay产品后将其置于-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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