- 中文名称
LAMB1 抗体
- 英文名字
- LAMB1 Antibody
- 供应商
- ProSci
- 产品货号
- PSI-57-398
- 产品报价
- ￥询价/400ul
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Laminins, a family of extracellular matrix glycoproteins,nare the major noncollagenous constituent of basement membranes.nThey have been implicated in a wide variety of biological processesnincluding cell adhesion, differentiation, migration, signaling,nneurite outgrowth and metastasis. Laminins are composed of 3 nonnidentical chains: laminin alpha, beta and gamma (formerly A, B1,nand B2, respectively) and they form a cruciform structurenconsisting of 3 short arms, each formed by a different chain, and anlong arm composed of all 3 chains. Each laminin chain is anmultidomain protein encoded by a distinct gene. Several isoformsnof each chain have been described. Different alpha, beta and gammanchain isomers combine to give rise to different heterotrimericnlaminin isoforms which are designated by Arabic numerals in thenorder of their discovery, i.e. alpha1beta1gamma1 heterotrimer isnlaminin 1. The biological functions of the different chains andntrimer molecules are largely unknown, but some of the chains havenbeen shown to differ with respect to their tissue distribution,npresumably reflecting diverse functions in vivo. This gene encodesnthe beta chain isoform laminin, beta 1. The beta 1 chain has 7nstructurally distinct domains which it shares with other beta chainnisomers. The C-terminal helical region containing domains I and IInare separated by domain alpha, domains III and V contain severalnEGF-like repeats, and domains IV and VI have a globularnconformation. Laminin, beta 1 is expressed in most tissues thatnproduce basement membranes, and is one of the 3 chains constitutingnlaminin 1, the first laminin isolated from Engelbreth-Holm-Swarmn(EHS) tumor. A sequence in the beta 1 chain that is involved inncell attachment, chemotaxis, and binding to the laminin receptornwas identified and shown to have the capacity to inhibitnmetastasis.
- 应用类型
- WB, IHC-P
- 免疫原
- This LAMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1691-1720 amino acids from the C-terminal region of human LAMB1.
- 来源宿主
- 兔
- 反应性
- 小鼠
- 保存建议
- Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- 其他
- ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。
- 注意
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