- 中文名称
CRYAB 抗体
- 英文名字
- CRYAB Antibody
- 供应商
- ProSci
- 产品货号
- PSI-57-208
- 产品报价
- ￥询价/400ul
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Crystallins are separated into two classes:ntaxon-specific, or enzyme, and ubiquitous. The latter classnconstitutes the major proteins of vertebrate eye lens and maintainsnthe transparency and refractive index of the lens. Since lensncentral fiber cells lose their nuclei during development, thesencrystallins are made and then retained throughout life, making themnextremely stable proteins. Mammalian lens crystallins are dividedninto alpha, beta, and gamma families; beta and gamma crystallinsnare also considered as a superfamily. Alpha and beta families arenfurther divided into acidic and basic groups. Seven protein regionsnexist in crystallins: four homologous motifs, a connecting peptide,nand N- and C-terminal extensions. Alpha crystallins are composed ofntwo gene products: alpha-A and alpha-B, for acidic and basic,nrespectively. Alpha crystallins can be induced by heat shock andnare members of the small heat shock protein (sHSP also known as thenHSP20) family. They act as molecular chaperones although they donnot renature proteins and release them in the fashion of a truenchaperone; instead they hold them in large soluble aggregates.nPost-translational modifications decrease the ability to chaperone.nThese heterogeneous aggregates consist of 30-40 subunits; thenalpha-A and alpha-B subunits have a 3:1 ratio, respectively. Twonadditional functions of alpha crystallins are an autokinasenactivity and participation in the intracellular architecture.nAlpha-A and alpha-B gene products are differentially expressed;nalpha-A is preferentially restricted to the lens and alpha-B isnexpressed widely in many tissues and organs. Elevated expression ofnalpha-B crystallin occurs in many neurological diseases; a missensenmutation cosegregated in a family with a desmin-related myopathy.
- 应用类型
- WB, IHC-P
- 免疫原
- This CRYAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-112 amino acids from the Central region of human CRYAB.
- 来源宿主
- 兔
- 反应性
- 人, 小鼠
- 保存建议
- Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- 其他
- ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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