- 中文名称
Mepolizumab (IL5) 抗体, 单克隆
- 英文名字
- Mepolizumab (IL5) Antibody, Monoclonal
- 供应商
- ProSci
- 产品货号
- PSI-10-123
- 产品报价
- ￥询价/0.1mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Mepolizumab is a humanized IL-5 antagonist monoclonal antibody produced by recombinant DNA technology in Chinese hamster ovary cells.It has a molecular weight of approximately 149 kDa.It was approved by the FDA in November,2015 for the treatment of asthma under the brand name Nucala (marketed by GlaxoSmithKline).Mepolizumab has been investigated in the treatment of severe nasal polyposis,among numerous other conditions.Mepolizumab is an interleukin-5 antagonist (IgG1 kappa).IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation,and survival of eosinophils.Mepolizumab binds to IL-5 with a dissociation constant of 100 pM,inhibiting the bioactivity of IL-5 by blocking its binding to the alpha chain of the IL-5 receptor complex expressed on the eosinophil cell surface.Inflammation is an important component in the pathogenesis of asthma. Multiple cell types (e.g., mast cells,eosinophils, neutrophils,macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) are involved in inflammation.Mepolizumab,by inhibiting IL-5 signaling, reduces the production and survival of eosinophils;however,the mechanism of mepolizumab action in asthma has not been definitively established.
- 应用类型
- 该ADAM10 抗体产品相关信息查看ProSci提供得说明书
- 免疫原
- Humanized / IL5 [Homo sapiens]
- 来源宿主
- 该ADAM10 抗体产品相关信息查看ProSci提供得说明书
- 反应性
- 该ADAM10 抗体产品相关信息查看ProSci提供得说明书
- 保存建议
- Store at -80˚C
- 其他
- ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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