SNRPD1 is a small nuclear ribonucleoprotein which is a member of the SNRNP core protein family. SNRPD1 may act as a charged protein scaffold to stimulate SNRNP assembly or strengthen SNRNP-SNRNP interactions via nonspecific electrostatic contacts with RNA. In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.