NACA belongs to the nascent polypeptide associated complex （NAC） alpha subunit family which takes part in inhibiting unsuitable targeting of non-secretory polypeptides to the endoplasmic reticulum （ER）. NACA proteins are usually restricted to the nucleus and cytoplasm and hold NAC-A/B （NAC-alpha/beta） and UBA （ubiquitin-associated） domains. The UBA domain is related to proteins which takes part in the ubiquitin-proteasome pathway for protein degradation.
