MYCBP is a member of the AMY1 family. MYCBP （c-Myc binding protein） binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP also associates with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm， suggesting a role for MYCBP in spermatogenesis. MYCBP is highly expressed in the heart， placenta， pancreas， skeletal muscle and kidney. It is also present at low levels in the lung.
