ARL3 （ARFL3） belongs to the ARF-like protein （ARL） subfamily of small GTPases. ARL3 does not activate the cholera toxin ADP-ribosyltranferase contrasting from ARFs. ARL3 is ubiquitously expressed. ARL3 may have a role in maintaining rod photoreceptor cells and regulating microtubule-dependent processes. ARL3 knockdown leads to altered cell morphology， failure of cytokinesis， acetylation of alpha tubulin and an increase in binucleated cells.
