Ephrin-B2 belongs to the ephrin （EPH） family. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated with mediating developmental events， particularly in the nervous system and in erythropoiesis. Based upon their structures and sequence relationships， ephrins are allocated into the ephrin-A （EFNA） class， which are anchored to the membrane by a glycosylphosphatidylinositol linkage， and the ephrin-B （EFNB） class， which are transmembrane proteins. Ephrin-B2 binds to the EPHB4 and EPHA3 receptors.
