PFDN5 is a member of the prefoldin alpha subunit family. Prefoldin （PFDN） being a ubiquitously expressed heterohexameric co-chaperone， is required for proper folding of nascent proteins， in particular， tubulin and actin. PFDN5 is one of 6 subunits of prefoldin， which is a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides， thus allowing them to fold properly. The PFDN5 protein may also limit the transcriptional activity of the proto-oncogene c-Myc.
