High mobility group protein HMG-I/HMG-Y （HMGA1） belongs to the non-histone chromosomal high mobility group protein （HMG） family. HMGA1 is composed of a highly conserved AT-hook DNA-binding domain which mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. HMGA1 functions as an architectural chromatin-binding transcription factor modifying the conformation of DNA by modulating nuclear protein-DNA complexes. Furthermore， HMGA1 is involved in numerous cellular processes including growth regulation， viral induction of beta-IFN gene and regulation of inducible gene transcription.
