RAD1 is part of a heterotrimeric cell cycle checkpoint complex， recognized as the 9-1-1 complex， that is activated to stop cell cycle progression in reaction to DNA damage or incomplete DNA replication. RAD1 complex withholds the Rad9 and Hus1 proteins and takes part in cellular responses to DNA damage， by associating with Rad17 and several components of the PCNA-loading heteropentamer， replication factor C. RAD1 takes part in DNA repair and recruited to DNA lesion upon damage by the RAD17-replication factor C （RFC） clamp loader complex. RAD1 takes part as a sliding clamp platform on DNA for several proteins that play a role in long-patch base excision repair （LP-BER）. RAD1 complex stimulates DNA polymerase beta （POLB） activity by raising its affinity for the 3’’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. RAD1 Human solution containing 20mM Tris pH-8， 1mM DTT， 0.2M NaCl & 10% glycerol.
保存建议
RAD1 Human although stable at 4℃ for 1 week， should be stored desiccated
below -18℃.
Please prevent freeze thaw cycles.
