CD163 is an acute phase-regulated receptor that takes part in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. CD163 participates in uptake and recycling of iron， via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. CD163 shows larger affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. CD163 stimulates a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization， inositol triphosphate creation and secretion of IL6 and CSF1.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The protein was lyophilized from a concentrated （1mg/ml） solution containing 20mM Phosphate buffer pH-7.4， 8M Urea and 0.15M NaCl. It is recommended to reconstitute the lyophilized CD163 in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized CD163 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution CD163 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
