TAGLN is a transformation and form-change responsive actin cross-linking/gelling protein that is part of the calponin family. TAGLN is expressed abundantly in fibroblasts and smooth muscle. TAGLN participates in calcium interactions and contractile properties of the cell that contribute to replicative senescence. Throughout embryogenesis， TAGLN is expressed in smooth， cardiac and skeletal muscle， but is limited during late fetal growth and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. TAGLN is downregulated in several transformed cell lines， showing that a decrease of TAGLN expression is an premature indicator of the onset of transformation.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. TAGLN Human solution containing 20mM Tris HCL pH-7.5， 1mM DTT， & 20% glycerol.
保存建议
TAGLN Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
