Calcium-binding protein P22 is a phosphoprotein that binds to the sodium-hydrogen exchangers （NHEs）. CHP is an essential cofactor which maintains the physiological activity of NHE family members. CHP has protein sequence resemblance to calcineurin B and it is also identified to be an endogenous inhibitor of calcineurin activity.CHP is necessary for constitutive membrane traffic. CHP Inhibits GTPase-stimulated Na（+）/H（+） exchange. CHP inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.
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大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. CHP Human solution containing 20mM Tris HCL pH-7.5， & 10% glycerol.
保存建议
CHP Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
