RUNX3 is part of the RUNX family that mediates the expression of genes which participate in cellular differentiation and cell cycle progression. RUNX3 heterodimer and the beta subunit form a complex that binds to the core DNA sequence 5’’-PYGPYGGT-3’’ found in several enhancers and promoters， and can either activate or suppress transcription. RUNX3 interacts with additional transcription factors. RUNX3 is a good candidate for gastric cancer tumor suppressor diagnosis.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. RUNX3 Human solution containing 20mM Tris HCL pH-8， 0.1M NaCl， & 20% glycerol.
保存建议
RUNX3 Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
