CALR is a multifunctional protein that acts as a main Ca（2+）-binding （storage） protein in the lumen of the endoplasmic reticulum. Calreticulin is localized in the nucleus， and participates in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR， which is nearly identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CALR binds to antibodies in specific sera of systemic lupus and Sjogren patients which have anti-Ro/SSA antibodies， it is well conserved among species， and it is positioned in the endoplasmic and sarcoplasmic reticulum where it binds calcium. The amino terminus of CALR interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CALR reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo， as well as retinoic acid-induced neuronal differentiation. Therefore， CALR acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. CALR Human solution containing 20mM Trsi HCL pH-8， 1mM DTT， 0.1M NaCl and 10% glycerol.
保存建议
CALR Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
