SQSTM1 is an adapter protein which binds ubiquitin and mediates the activation of NFKB1 by TNF-a， NGF and IL-1. SQSTM1 is involved in titin/TTN downstream signaling in muscle cells. SQSTM1 controls signaling cascades through ubiquitination. SQSTM1 participates in cell differentiation， apoptosis， immune response and regulation of K（+） channels. Mutations in UBA domain of the SQSTM1 protein cause Paget’s disease because the UBA is essential for aggregate sequestration and cell survival.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. SQSTM1 Human solution containing 20mM Trsi HCL pH-8， 1mM DTT and 10% glycerol.
保存建议
SQSTM1 human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
