TSG101 is a member of apparently inactive homologs of ubiquitin-conjugating enzymes. TSG101 contains a coiled-coil domain that interacts with stathmin， a cytosolic phosphoprotein implicated in tumorigenesis. TSG101 is involved in cell growth and differentiation and acts as a negative growth regulator. TSG101 in vitro steady-state expression is important for maintenance of genomic stability and cell cycle regulation. TSG101 mutations and alternative splicing occur in high rate in breast cancer and implicate that defects occur during breast cancer tumorigenesis and/or progression. TSG101 is a factor of the ESCRT-I complex， a monitor of vesicular trafficking process. TSG101 binds to ubiquitinated cargo proteins and is needed for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. TSG101 is needed for completion of cytokinesis and is involved in cell growth and differentiation.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. TSG101 Human solution containing 20mM Trsi HCL pH-8， 1mM DTT and 10% glycerol.
保存建议
TSG101 human although stable at 4ºC for 1 week， should be stored desiccated below -18ºC. Please prevent freeze thaw cycles.
