CASQ2 belongs to the calsequestrin family and is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. CASQ2 is a calcium binding protein that stores calcium for muscle function. The discharge of calcium bound to CASQ2 through a calcium release channel activates muscle contraction. CASQ2 binds 40 to 50 moles of calcium. CASQ2 mutations result in stress-induced polymorphic ventricular tachycardia， also called catecholaminergic polymorphic ventricular tachycardia 2 which is known fir its bidirectional ventricular tachycardia that causes cardiac arrest.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear colorless solution. The CASQ2 solution contains 20mM Tris-HCl pH-8， 0.1M NaCl， 1mM DTT and 20% glycerol.
保存建议
CASQ2 Recombinant Human although stable at 4℃ for 30 days， should be stored desiccated below -20℃ for periods greater than 30 days. Please avoid freeze-thaw cycles.
