CRNN is part of the "fused gene" family of proteins， which enclose N-terminus EF-hand domains and multiple tandem peptide repeats. CRNN contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. CRNN， also known as SEP53， which participates in the mucosal/epithelial immune response and epidermal differentiation. CRNN is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines， attenuates deoxycholic acid （DCA）-induced apoptotic cell death and discharge of calcium. When CRNN is over expressed in oral squamous carcinoma cell lines， it regulates negatively cell proliferation by the induction of G1 arrest.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear colorless solution. The CRNN solution contains 20mM Tris-HCl pH-8 and 10% glycerol.
保存建议
CRNN Recombinant Human although stable at 4℃ for 30 days， should be stored desiccated below -20℃ for periods greater than 30 days. Please avoid freeze-thaw cycles.
