PDCD6IP is a Class E VPS protein which participates in concentration and sorting of cargo proteins of the multivesicular body or incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. PDCD6IP binds to the phospholipid lysobisphosphatidic acid which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O， -I，-II and -III complexes. PDCD6IP is an adapter for a subset of ESCRT-III proteins， such as CHMP4， to function at distinct membranes. PDCD6IP is mandatory for completion of cytokinesis. PDCD6IP takes part in HIV-1 virus budding. PDCD6IP replaces TSG101 in its function of supporting HIV-1 release. PDCD6IP takes part in the regulation of both apoptosis and cell proliferation. PDCD6IP is a cytoplasmic protein that cooperates with apoptosis-associated proteins （ALG-2 and PDCD6） and with the endocytosis-regulator CIN85. Overexpression of PDCD6IP and endophilin
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The protein solution contains 20mM Tris-HCl pH-8， 1mM DTT and 10% glycerol.
保存建议
PDCD6IP although stable 4℃ for 4 weeks， should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
