HEXIM1 expression is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. HEXIM1 is a transcriptional regulator which acts as a universal RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex inhibits RNA polymerase II phosphorylation following transcriptional elongation. HEXIM1 regulates NF-kappa-B， ESR1， NR3C1 and CIITA-dependent transcriptional activity.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. HEXIM1 solution containing 20mM Tris pH-8， 0.1M NaCl and 10% glycerol.
保存建议
HEXIM1 Human Recombinant although stable at 4℃ for 1 week， should be stored below -18℃. Please prevent freeze thaw cycles.
