Syndecan-4 is a type I integral membrane heparan sulfate proteoglycan （HSPG）， which was originally isolated from cloned rat microvascular endothelial cells as an antithrombin-binding molecule， and is now known to be a member of the syndecan family. Syndecan-4 binds to basic fibroblast growth factor （bFGF）， midkine， and tissue factor pathway inhibitor via its heparan sulfate chains， and is thought to be involved in various biologic functions such as signaling of bFGF， anticoagulation， and focal adhesion formation. A previous study demonstrated that syndecan-4 is expressed in various tissues， and its level of expression in the kidney is stronger than those of other syndecan family members. Thus， syndecan-4 is thought to play certain roles in maintaining renal function. Moreover， it has been reported that proteoglycans， especially sulfated proteoglycans， are involved in organogenesis of the kidney.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. SDC4 solution containing 20mM Tris pH-8， and 10% glycerol.
保存建议
SDC4 Human Recombinant although stable at 4℃ for 1 week， should be stored below -18℃. Please prevent freeze thaw cycles.
