ANXA2 is part of the annexin family and is involved in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein functions as an autocrine factor which increases osteoclast formation and bone resorption. ANXA2 is associated with sickle cell osteonecrosis. Reduced ANXA2 expression is associated with osteosarcoma metastases. ANXA2 is part of the putative cell surface vitamin D binding protein binding site complex and functions to mediate the chemotactic cofactor effect. ANXA2 is involved in dysferlin deficiency and in muscular dystrophies. Human colon adenocarcinoma cell differentiation is related with an up-regulation of ANXA2.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. ANXA2 solution containing 20mM Tris pH-8， 0.1M NaCl and 10% glycerol.
保存建议
ANXA2 Human Recombinant although stable at 4℃ for 1 week， should be stored below -18℃. Please prevent freeze thaw cycles.
