ENSA is an endogenous ligand for sulfonylurea receptor. ENSA reduces K（ATP） channel currents by inhibiting sulfonylurea from binding to the receptor and thus stimulates insulin secretion. Endosulfine Alpha is part of a conserved cAMP-regulated phosphoprotein （ARPP） family. Endosulfine Alpha is an endogenous ligand for the sulfonylurea receptor， ABCC8/SUR1. Endosulfine Alpha is an endogenous regulator of KATP channels. ENSA modulates insulin secretion through the interaction with KATP channel. ENSA is a candidate gene for type 2 diabetes. ENSA is expressed in a wide range of tissues including muscle， brain， and endocrine tissues.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The Endosulfine Alpha protein solution contains 20mM Tris， pH-8， 1mM DTT and 10% glycerol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles.
