SERPINA5 up regulateS TAFI activation by inhibiting the protein C activation. SERPINA5 is an significant regulator in the equilibrium between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of Protein-C. SERPINA5 belongs to the serpin serine proteinase inhibitor family. SERPINA5 protein inhibits plasminogen activators as well as activated protein C.
SERPINA5 is secreted in plasma and liver. SERPINA5 is involved in cell inflammation， proliferation， apoptosis， tumour cell migration， invasion， and metastasis. SERPINA5 controls the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by the cells. SERPINA5 plays a role in regulating key serine proteases involved in metastatic prostate disease. The heparin binding site of SERPINA5 inhibitor is protease-dependent.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The SERPINA5 solution contains 20mM Tris-HCl buffer pH-8.， 1mM DTT， and 10% glycerol.
保存建议
SERPINA5 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
