Calnexin （CANX） belongs to the calnexin family of molecular chaperones. Calnexin is a calcium-binding， ER-associated protein that interacts briefly with newly synthesized N-linked glycoproteins， facilitating protein folding and assembly. Calnexin may also have a key role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Calnexin grants long-term protection of wild-type Shaker protein from ER-associated degradation. Polypeptide substrate recognition by Calnexin requires specific conformations of the Calnexin protein. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The CANX protein solution contains 20mM Tris-HCl buffer （pH8.0）， 1mM DTT and 20% glycerol.
保存建议
CANX although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
