Calbindin 1 （CALB1） is a calcium binding protein that is a member of the troponin C superfamily. CALB1 plays a vital role in calcium regulation （including calcium transport and uptake， calcification of bone and teeth） and calcium associated signaling in neurons and transiently in embryological development. CALB1 also has a role in protecting neurons from apoptotic cell death. CALB1 buffers cytosolic calcium and may stimulate a membrane Ca2+-ATPase and a 3’，5’-cyclic nucleotide phosphodiesterase. The biological function of CALB1 seems to be tied to the redox state of its five cysteine residues.
CALB1 has 4 active calcium-binding domains， and 2 modified domains that seemingly have lost their calcium-binding ability. CALB1 is expressed in neural tissues. In the brain， the CALB1 synthesis is independent of vitamin-D-derived hormones.
Disregulation of the CALB1 is associated with epilepsy， amyotrophic lateral sclerosis， Huntington’s disease. The neurons in brains of Huntington disease patients are calbindin-depleted.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The CALB1 protein solution contains 20mM Tris-HCl buffer （pH8.0）， 1mM DTT， 10% glycerol and 2mM EDTA.
保存建议
CALB1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
