NDK （Nucleoside diphosphate kinase） exists as a hexamer composed of ’A’ （encoded by NME1） and ’B’ （encoded by NME2） isoforms. NME1 is involved in cell proliferation， differentiation and development， signal transduction， G protein-coupled receptor endocytosis， and gene expression. It also has tumor metastasis-suppressive capacity. NME1 has a key role in the synthesis of nucleoside triphosphates other than ATP. NME1 is essential for neural development including neural patterning and cell future determination.
The NME1 gene is expressed in various tumor types where its levels have been alternatively linked to reduced or increased metastatic potential.
Decrease in NME1 expression is notably connected to aggressive behavior in melanoma， breast， colon， and gastric carcinomas. In contrast， elevated levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas.
Somatic mutations of the NME1 gene are found in neuroblastoma. Increased NME1 in neuroblastoma is linked to features of the disease that are associated with aggressive tumors.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The NME1 solution contains 20mM Tris-HCl buffer （pH7.5）， 1mM DTT and 10% glycerol.
保存建议
NME1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
