TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins （cofactors A， D， E， and C） implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A and D are thought to be a factor in capturing and stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability， if reduced it causes a decrease in the amount of soluble tubulin， alterations in microtubules and G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex， afterward， interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The TBCA solution contains 20mM Tris-HCl buffer pH 7.5， 1mM DTT and 10% glycerol.
保存建议
TBCA although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
