HINT1， also known as Histidine triad nucleotide-binding protein 1 is part of the superfamily named for a near C-terminal HXHXHXX motif （H:Histidine， X:a hydrophobic amino acid） positioned at the ?-phosphate of nucleotide substrates. HINT1 hydrolyzes adenosine 5’-monophosphoramidate substrates such as AMP-morpholidate， AMP-N-alanine methyl ester， AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Though it was initially considered to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- ， its actual physiologic function is not known.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The HINT1 solution contains 20mM Tris pH-8 & 10% glycerol.
保存建议
HINT1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
