SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus， where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta， and therefore regulates multiple cellular processes， such as cell proliferation， apoptosis， and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation （SARA） protein.
TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
序列
请咨询我们客服或者请查看品牌官方网站
来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The SMAD2 protein solution contains 20mM Tris-HCl pH-8， and 100mM NaCl.
保存建议
SMAD2 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
