ANXA1 is part of the family of Ca（2+）-dependent phospholipid binding proteins which have a Mw between 35kDa-40kDa and are situated on the cytosolic face of the plasma membrane. ANXA1 protein has a Mw of 40kDa， with phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity. Since phospholipase A2 is necessary for the biosynthesis of the potent mediators of inflammation， prostaglandins and leukotrienes， ANXA1 might have potential anti-inflammatory activity. ANXA1 promotes membrane fusion and iplays a role in exocytosis. The recognition of ANXA1 protein by immunocytochemical leads a simple， highly sensitive and specific assay for diagnosis of hairy cell leukemia.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The ANXA1 protein solution contains 20mM Tris-HCl， pH-8， 100mM NaCl， 1mM DTT and 10% glycerol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
