SPG21 binds to the hydrophobic C-terminal amino acids of CD4 which take part in suppression of CD-4 dependant T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain. SPG21 adapts the stimulatory activity of CD4. SPG21 is broadly expressed in diverse tissues including heart， brain， placenta， lung， liver， skeletal muscle， kidney and pancreas. Mutations in SPG21 cause Mast syndrome， an autosomal-recessive complicated form of hereditary spastic paraplegia characterized by dementia， thin corpus callosum and white matter abnormalities.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The SPG21 protein solution contains 20mM Tris-HCl， pH-8.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
