CPLX1 is part of the SNARE family complex binding proteins that are catalysts or inhibitors of vesicle exocytosis. CPLX1 shows reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses， indicating that CPLX1 is a positive regulator of transmitter release. In contrast， CPLX1 inhibits SNARE-mediated liposome and cell fusions in vitro， that result in hypothesis thus acts as a fusion clamp of synaptic exocytosis. CPLX1 regulates a late step in synaptic vesicle exocytosis. CPLX1 takes part in glucose-induced secretion of insulin by pancreatic beta-cells.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The CPLX1protein solution contains 20mM Tris-HCl pH-8 and 10% glycerol.
保存建议
CPLX1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
