Podoplanin is a small mucin-like type-1 transmembrane protein， typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN physiological function is related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor.
PDPN is expressed in lymphatic progenitor cells and afterwards during mouse development in lymphatic endothelial cells. Podoplanin is a specific marker for lymph vessel endothelial cells. Over-expression of podoplanin significantly elevates endothelial cell adhesion， migration， and tube formation. Inhibition of Podoplanin expression decreases cell adhesion in human dermal lymphatic endothelial cells. Podoplanin is used as a specific marker for lymphatic endothelium in histopathology.
Podoplanin expression is increased in nearly all human colon， rectum， and small intestine tumors. AGGRUS may serve as a diagnostic marker that distinguishes seminomas， the majority of which over express the protein， from embryonal carcinoma in testicular germ cell tumors.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The protein solution contains 20mM Tris-HCl pH7.5 & 0.1M NaCl.
保存建议
Podoplanin although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
