Retinoic acid receptor alpha （RAR） belongs to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. There are three isotypes of RAR proteins: alpha， beta， and gamma. The RAR proteins are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically， RAR-alpha represses target gene transcription in the absence of hormone， whereas RAR-beta and gamma fail to repress under these conditions. RARA is a receptor for retinoic acid that has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. RARA controls cell function by directly regulating gene expression.
Chromosomal aberrations involving RARA cause acute promyelocytic leukemia （APL）.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The protein solution contains 20mM Tris pH-7.5， 0.1M NaCl & 5mM ?-ME.
保存建议
RARA although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
