Retinoblastoma （RB） is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression （’cure’） occurs in some cases. Retinoblastoma acts as a regulator of other genes and forms a complex with adenovirus e1a and with sv40 large t antigen. Retinoblastoma acts as a tumor suppressor and modulats functionally certain cellular proteins with which t and e1a compete for pocket binding. Retinoblastoma is potent inhibitor of e2f-mediated trans-activation， recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression， inhibits the intrinsic kinase activity of taf1.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The RB1 （1 mg/ml） was lyophilized after extensive dialyses against 1xPBS pH-7.4. It is recommended to reconstitute the lyophilized Retinoblastoma in sterile 18MΩ-cm H2O not less than 100 ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized Retinoblastoma although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Retinoblastoma should be stored at 4℃ between 2-7 days and for future use below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
