Alpha-2 Macroglobulin is a serine proteases inhibitor， which inhibits coagulation by inactivating thrombin and Kallikrein， it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein， which is produced by the liver， it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases （including serine-， cysteine-， aspartic- and metalloproteinases）. ?2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to ?2M. Macrophage receptors recognize the proteinase-?2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 （active forms of the gelatinase） from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size， ?2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes ?2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis， pregnancy and diabetes.
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来源宿主
人血浆中提取纯化
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. Lyophilized from 0.02M TRIS， 0.15M NaCl and 0.1M Sucrose， pH 8.0.
保存建议
Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks， should be stored between 2-8℃.
