TES also called Testin is a tumor suppressor protein which is involved in cell adhesion， cell spreading and in the restructuring of the actin cytoskeleton. TES protein localizes to cell-cell contacts and actin stress fibres， and interacts with a diversity of cytoskeletal proteins such as Zyxin， Mena， VASP， Talin and Actin. The ability of TES to associate with alpha-actinin， paxillin and Zyxin is dependent on the conformational form of the protein.
