EIF4EBP1 （eukaryotic translation initiation factor 4E-binding protein 1） belongs to a family of translation repressor proteins. EIF4EBP1 regulates eIF4E （eukaryotic translation initiation factor 4E） activity by preventing its assembly into the eIF4F complex and mediates the regulation of protein translation by hormones， growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling， resulting in its dissociation from eIF4E and activation of mRNA translation. EIF4EBP1 C-terminus has domains which control function and phosphorylation. EIF4EBP1 has a role in progression of breast neoplasms through cell signaling.
序列
请咨询我们客服或者请查看品牌官方网站
来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The EIF4EBP1 solution contains 20mM Tris-HCl buffer （pH8.0） and 10% glycerol.
保存建议
EIF4EBP1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
